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Funded Since: Funding Source: U. The main cohort, called the Life Span Study LSS , consisted of about , persons of all ages and both genders in of whom more than 90, were exposed to atomic bomb radiation, with a wide range of exposure doses. About 45, LSS participants completed questionnaires in the late s and periodically since then on sociodemographic, lifestyle, and other disease risk factors.
Mortality and cancer incidence follow-up of the LSS cohort is continuing, and about 40 percent of participants are still alive.
The numerous published results have included papers on cancer incidence in relation to radiation and other risk factors, histopathologic studies of various cancer sites, factors that serve as effect-modifiers, and molecular studies of selected cancers.
A clinical subsample, the Adult Health Study AHS , of about 17, participants was established in and has received biennial clinical examinations since that time. Extensive clinical data, along with sociodemographic, lifestyle, and medical history information, are available on AHS participants, and biological samples were stored beginning in The AHS data permit studies on pre-clinical conditions, disease biomarkers, and non-cancerous diseases.
In , a study was initiated to clinically examine about 12, children of the atomic bomb survivors, and preparations are currently under way for a longitudinal study of this cohort. Epidemiology and Genomics Research Program. Return to Top.